Shop At Home Lab Tests SHOP ALL → Bars & DrinksBars & SnacksElectrolyte DrinksEnergy DrinksProtein Drinks SHOP ALL → Bundle & Save SHOP ALL → CBD SHOP ALL → Diet & Weight ManagementBlood Sugar SupportThermogenicsWeight Management SHOP ALL → Essential Oils & Aromatherapy SHOP ALL → Fitness AccessoriesHeart Rate MonitorsPillowsWatch AccessoriesWatches SHOP ALL → Immunity & WellnessImmunityMineralsMultivitaminsVitamins SHOP ALL → Joints Support & OmegasFish OilJoints SupportPlant Based Omegas SHOP ALL → Men's HealthMen's Sexual HealthProstate SupportTestosterone Support SHOP ALL → On Sale ProductsFLASH SALEThis Week's Sale SHOP ALL → Performance & RecoveryNon-Stim Pre-WorkoutsPerformancePre-WorkoutsRecovery SHOP ALL → Probiotics & DigestionCleanse & DetoxDigestion SupportProbiotics SHOP ALL → ProteinPlant Based ProteinWhey Protein SHOP ALL → Superfoods & Plant BasedGreens MixesSuperfoodsVegan Products SHOP ALL → Targeted HealthBrain & Eye HealthHeart HealthLiver HealthStress & Sleep SHOP ALL → Women's HealthBone HealthHair, Skin, & NailsHormone SupportWomen's Sexual Health SHOP ALL → LATEST PRODUCTS Fitness FitnessEssential Amino Acids Support Muscle Protein Synthesis FitnessMaximizing Recovery After Training & Competition FitnessThe Keto Diet Plan May Benefit Body Builders FitnessHigh Intensity Interval Exercise VS Moderate Intensity, Continuous Training Health & WellnessTop Five Tips to Avoid Training too Much FitnessVitamins and Minerals to Improve Adolescent Fitness Fitness Topics PerformanceRecovery Latest in Fitness Health & Wellness Health & WellnessNutritional Factors May Modify Risk to Covid-19 Health & WellnessCOVID-19: Vitamin D May Modulate Risk & Severity Health & WellnessFish Oil Lowers Cardiovascular Disease Risk Health & WellnessTeenagers Top Five Foods for Success Health & WellnessResearch Confirms Optimum Vitamin D Blood Values Vitamins & MineralsAre Multivitamins Right for You? Health & Wellness Topics Health & Wellness ProductsImmunityMen's HealthWomen's Health Latest in Health & Wellness Nutrition NutritionTop Five Foods to Fight Inflammation RecipesHigh Protein Blue Berry Pancakes NutritionThe Top Five Healthy Foods for Women High Protein RecipesEgg & Turkey Stuffed Peppers Low Carb RecipesHearty Breakfast Sausage NutritionAre Cleansing Supplements Right for You? Nutrition Topics Nutrition ProductsRecipesVitamins & MineralsWeight Management Latest in Nutrition WEB SERIES Maximum Wellness Workout Wednesday LATEST IN WEB SERIES Shop SHOP At Home Lab Tests Bars & Drinks Bundle & Save CBD Diet & Weight Management Essential Oils & Aromatherapy Fitness Accessories Immunity & Wellness Joints Support & Omegas Men's Health On Sale Products Performance & Recovery Probiotics & Digestion Protein Superfoods & Plant Based Targeted Health Women's Health LATEST PRODUCTS Fitness Fitness Topics Performance Recovery Fitness Essential Amino Acids Support Muscle Protein Synthesis Fitness Maximizing Recovery After Training & Competition Fitness The Keto Diet Plan May Benefit Body Builders Fitness High Intensity Interval Exercise VS Moderate Intensity, Continuous Training Health & Wellness Top Five Tips to Avoid Training too Much Fitness Vitamins and Minerals to Improve Adolescent Fitness Latest in Fitness Health & Wellness Health & Wellness Topics Health & Wellness Products Immunity Men's Health Women's Health Health & Wellness Nutritional Factors May Modify Risk to Covid-19 Health & Wellness COVID-19: Vitamin D May Modulate Risk & Severity Health & Wellness Fish Oil Lowers Cardiovascular Disease Risk Health & Wellness Teenagers Top Five Foods for Success Health & Wellness Research Confirms Optimum Vitamin D Blood Values Vitamins & Minerals Are Multivitamins Right for You? Latest in Health & Wellness Nutrition Nutrition Topics Nutrition Products Recipes Vitamins & Minerals Weight Management Nutrition Top Five Foods to Fight Inflammation Recipes High Protein Blue Berry Pancakes Nutrition The Top Five Healthy Foods for Women High Protein Recipes Egg & Turkey Stuffed Peppers Low Carb Recipes Hearty Breakfast Sausage Nutrition Are Cleansing Supplements Right for You? Latest in Nutrition WEB SERIES WEB SERIESpodcastsMaximum Wellness podcastsWorkout Wednesday LATEST IN WEB SERIES Maximum Wellness Maximum Wellness, Episode 30: Curcumin: much more than just a spice Date January 22, 2020 Curcumin (curcuma longa linn) – a polyphenol compound extracted from the spice turmeric—offers multiple biological activities. Research has pointed to the potential benefits of curcumin, as an associated therapy in oxidative stress diseases, such as neurological disorders. “Curcumin, Hormesis, and the Nervous System,” a research paper published in the October 2019, issue of the journal Nutrients, notes that, “there is growing evidence indicating that oxidative stress contributes to the etiology and the progression of neurodegenerative diseases, such as Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis.” However, the same research also points out that, “evidence-based medicine has clearly demonstrated the lack of any therapeutic effect of curcumin to contrast the onset or progression of neurodegeneration and related diseases.” With advanced age, the effects of oxidative stress on brain function—known as neuro-inflammaging—has taken center stage in a search for compounds, like curcumin, which might offer good therapeutic treatment options. Italian researchers focused on the evidence related to the “hermetic effects” of curcumin relative to neuro-cognitive diseases. Hormesis is, “a term used by toxicologists to refer to a biphasic dose response to an environmental agent characterized by a low dose stimulation or beneficial effect and a high dose inhibitory or toxic effect.” One large issue with the use of curcumin as an adjunct to therapy or a stand-alone compound is its hydrophobic property—being poorly soluble in water. “The poor intestinal absorption, structural instability, limited blood brain barrier penetration, and rapid degradation of curcumin in the body limits the potential, as a therapeutic agent in clinical trials,” according to the Italians. Therefore, note the researchers, “an important aspect for the development of curcumin as a novel “nutraceutical’’ formulation deals with obtaining an increased bioavailability and physiological stability and solubility of this compound in animal models and humans.” Much of the scientific interest has to do with curcumin’s potential to affect the central nervous system and protection from beta amyloid plaque—a prerequisite to neuro-degenerative diseases like Alzheimer’s. While curcumin is a natural product, it’s not without potential safely concerns, such as a potential toxic effect though its interaction with drug metabolism enzymes. One such interaction involves the issues associates with curcumin concurrent with tamoxifen—an antagonist to estrogen receptors, which is used as an adjuvant therapy in women with breast cancer.” Furthermore, note the Italian researchers, curcumin has been shown to pose some adverse effects to the liver, under certain circumstances at high doses. Yet, the researchers conclude that, “with regard to the potential clinical efficacy of curcumin, there are several pre-clinical data in the literature confirming that curcumin possesses neuroprotective and cognitive-enhancing properties that may help delay or prevent neurodegenerative diseases.” The best advice is to take Buddha’s recommendation and, “be moderate in all things.” Check with your doctor first.