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Nutrition Topics Nutrition ProductsRecipesVitamins & MineralsWeight Management Latest in Nutrition WEB SERIES Maximum Wellness Workout Wednesday LATEST IN WEB SERIES Shop SHOP At Home Lab Tests Bars & Drinks Bundle & Save CBD Diet & Weight Management Essential Oils & Aromatherapy Fitness Accessories Immunity & Wellness Joints Support & Omegas Men's Health On Sale Products Performance & Recovery Probiotics & Digestion Protein Superfoods & Plant Based Targeted Health Women's Health LATEST PRODUCTS Fitness Fitness Topics Performance Recovery Fitness Essential Amino Acids Support Muscle Protein Synthesis Fitness Maximizing Recovery After Training & Competition Fitness The Keto Diet Plan May Benefit Body Builders Fitness High Intensity Interval Exercise VS Moderate Intensity, Continuous Training Health & Wellness Top Five Tips to Avoid Training too Much Fitness Vitamins and Minerals to Improve Adolescent Fitness Latest in Fitness Health & Wellness Health & Wellness Topics Health & Wellness Products Immunity Men's Health Women's Health Health & Wellness Nutritional Factors May Modify Risk to Covid-19 Health & Wellness COVID-19: Vitamin D May Modulate Risk & Severity Health & Wellness Fish Oil Lowers Cardiovascular Disease Risk Health & Wellness Teenagers Top Five Foods for Success Health & Wellness Research Confirms Optimum Vitamin D Blood Values Vitamins & Minerals Are Multivitamins Right for You? Latest in Health & Wellness Nutrition Nutrition Topics Nutrition Products Recipes Vitamins & Minerals Weight Management Nutrition Top Five Foods to Fight Inflammation Recipes High Protein Blue Berry Pancakes Nutrition The Top Five Healthy Foods for Women High Protein Recipes Egg & Turkey Stuffed Peppers Low Carb Recipes Hearty Breakfast Sausage Nutrition Are Cleansing Supplements Right for You? Latest in Nutrition WEB SERIES WEB SERIESpodcastsMaximum Wellness podcastsWorkout Wednesday LATEST IN WEB SERIES Maximum Wellness Maximum Wellness, Episode 60: Immune Support Update Date August 18, 2020 According to the World Health Organization, the worldwide estimate of influenza-related, severe illness is 3 to 5 million cases, which require hospitalizations—with roughly 290,000 to 650,000 deaths annually. Acute respiratory illnesses approximated 2.8 million deaths worldwide in 2016. Severe, lower respiratory tract infections, such as the SARS-CoV-2 infection leading to COVID-19 disease, were the most common cause of sepsis-related deaths globally from 1990-2017. Mayoclinic.org says, “sepsis is a potentially life-threatening condition caused by the body’s response to an infection. The body normally releases chemicals into the bloodstream to fight an infection. Sepsis occurs when the body’s response to these chemicals is out of balance, triggering changes that can damage multiple organ systems.” Our body’s defense mechanisms include the fast, non-antigen (virus) specific innate and the latent, slower antigen-specific (memory of past infection) adaptive immune response. The innate system reacts rapidly to search and destroy “non-self” threats—specifically though an inflammatory response, which is followed by damage repair from the attack. The adaptive attack comes in the form of T and B lymphocytes, which secrete antibodies that are specific to the infecting pathogen—causing an immunological memory recall for future responses to the same pathogen. There are specific nutritional strategies, which support optimal immune function. According to Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect Against Viral Infections, which appeared in the journal Nutrients in 2020, “several vitamins, including vitamins A, B6, B12, C, D, E, and folate; and trace elements, including zinc, iron, selenium, magnesium, and copper, play important and complementary roles in supporting both the innate and adaptive immune systems.” Other nutrients, such as omega-3 fatty acids, also support an effective immune system–specifically by helping to resolve the inflammatory response. The study authors from the University of Southampton (United Kingdom), Oregon State University, University of Otago (New Zealand), and the University Medical Center (Netherlands), comment that, “vitamin C affects several aspects of immunity, including supporting epithelial barrier function, growth and function of both innate and adaptive immune cells, white blood cell migration to sites of infection, phagocytosis and microbial killing, and antibody production,” Vitamin D metabolites, note the researchers, “appear to regulate production of specific antimicrobial proteins that directly kill pathogens, and thus are likely to help reduce infection including in the lungs.” In order to resolve the inflammatory immune response, the omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are sent to the site, “enzymatically converted to specialized pro-resolving mediators (SPMs) known as resolvins, protectins, and maresins. These molecules, along with others, function together to orchestrate the resolution of inflammation and to support healing, including in the respiratory tract.” As for recommended supplementation, the study authors cite a recent meta-analysis on upper and lower respiratory infections. “Based on this evidence, a daily intake of at least 200 mg/day for healthy individuals is recommended,” for vitamin C. This (level) is above the US RDA of 75 and 90 mg/day for female and male adults, respectively.” As for Vitamin D supplemental intake, “a daily intake of 2000 IU (50 ?g) is recommended.” However, this amount is also above the US RDA of 400–800 IU (depending on age). For Omega-3 fatty acids, “an intake of 250 mg EPA + DHA per day is recommended–consistent with global, regional, and national expert recommendations,” according to the study. Let me be clear. Before you make any decision to add or amend your intake of nutritional supplements during times of immune challenges, it’s best to get your daily nutrition plan in order. Then, check with your personal physician for guidance—consistent with your personal health profile.