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Nutrition Topics Nutrition ProductsRecipesVitamins & MineralsWeight Management Latest in Nutrition WEB SERIES Maximum Wellness Workout Wednesday LATEST IN WEB SERIES Shop SHOP At Home Lab Tests Bars & Drinks Bundle & Save CBD Diet & Weight Management Essential Oils & Aromatherapy Fitness Accessories Immunity & Wellness Joints Support & Omegas Men's Health On Sale Products Performance & Recovery Probiotics & Digestion Protein Superfoods & Plant Based Targeted Health Women's Health LATEST PRODUCTS Fitness Fitness Topics Performance Recovery Fitness Essential Amino Acids Support Muscle Protein Synthesis Fitness Maximizing Recovery After Training & Competition Fitness The Keto Diet Plan May Benefit Body Builders Fitness High Intensity Interval Exercise VS Moderate Intensity, Continuous Training Health & Wellness Top Five Tips to Avoid Training too Much Fitness Vitamins and Minerals to Improve Adolescent Fitness Latest in Fitness Health & Wellness Health & Wellness Topics Health & Wellness Products Immunity Men's Health Women's Health Health & Wellness Nutritional Factors May Modify Risk to Covid-19 Health & Wellness COVID-19: Vitamin D May Modulate Risk & Severity Health & Wellness Fish Oil Lowers Cardiovascular Disease Risk Health & Wellness Teenagers Top Five Foods for Success Health & Wellness Research Confirms Optimum Vitamin D Blood Values Vitamins & Minerals Are Multivitamins Right for You? Latest in Health & Wellness Nutrition Nutrition Topics Nutrition Products Recipes Vitamins & Minerals Weight Management Nutrition Top Five Foods to Fight Inflammation Recipes High Protein Blue Berry Pancakes Nutrition The Top Five Healthy Foods for Women High Protein Recipes Egg & Turkey Stuffed Peppers Low Carb Recipes Hearty Breakfast Sausage Nutrition Are Cleansing Supplements Right for You? Latest in Nutrition WEB SERIES WEB SERIESpodcastsMaximum Wellness podcastsWorkout Wednesday LATEST IN WEB SERIES Maximum Wellness Maximum Wellness, Episode 62: Co-Enzyme Q10 Improves Endothelial Function Date September 2, 2020 Abnormal blood lipids—such as alterations in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-C)—are major risk factors for cardiovascular disease (CVD). Known collectively as dyslipidemia, these abnormal lipid fractions have a prevalence of 38.6% among individuals aged 40 and above—with alterations of one out of five US children and adolescents aged 8 to17 years—according to research—Ubiquinol (CO Enzyme Q10) Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial, which appeared in the August 2020 issue of the journal Nutrients. The endothelium is the largest organ in the body—composed of a layer of cells that lies between the wall of blood vessels and the bloodstream. It is a living shield that keeps the arteries clear of build-up and blockage, so that essential oxygen and nutrients can get to the vital organs of the body. In addition, endothelial cells are involved in many aspects of vascular structure—acting as a barrier between the vessel lumen and surrounding tissue, while controlling the passage of materials and the transit of white blood cells into and out of the bloodstream. The authors of the Nutrients study from South Africa and Italy state that, “The impairment of endothelial function (EF) predates the morphological changes of atherosclerosis and can mechanistically contribute to atherosclerosis-related diseases.” Endothelial function can be assessed by flow mediated dilation (FMD), which, “assumes that endothelial dysfunction (ED) is a systemic process involving the coronary arteries, as well as, the peripheral circulation.” Using ultrasound technology, FMD estimates, “the dilation of a large peripheral conduit artery, typically the brachial artery, in response to the increased blood flow resulting from the removal of a transient ischemic stimulus.” FMD has proved effective in evaluating the impact of several interventions on ED. The researchers point out that coenzyme Q10 (CoQ10)—especially in its reduced form known as ubiquinol—”has improved endothelium-dependent vasodilation, as measured by FMD, in patients with type 2 diabetes, or coronary artery disease (CAD). However, the evidence of its effect on ED in subjects without clinical manifestations of atherosclerosis-related disease is limited.” Mayoclinic.org states that CoQ10, “is an antioxidant that your body produces naturally. Your cells use CoQ10 for growth and maintenance. Levels of CoQ10 in your body decrease as you age. CoQ10 levels have also been found to be lower in people with certain conditions, such as heart disease.” CoQ10 is found in meat, fish and whole grains. The amount of CoQ10 found in these dietary sources, according to Mayo, isn’t enough to significantly increase CoQ10 levels in your body. The Nutrient study authors sought to determine whether an 8-week ubiquinol supplementation period enhanced endothelium-dependent vasodilation in adults with moderate, untreated dyslipidemia and without evidence of CVD. The researchers recruited fifty-one subjects with low-density lipoprotein (LDL) cholesterol levels of 130-200 mg/dL, who were not taking statins or other lipid lowering treatments—with moderate (2.5%–6.0%) endothelial dysfunction, as measured by flow-mediated dilation (FMD) of the brachial artery, and no clinical signs of cardiovascular disease. During the study period, the participants were randomized to receive either ubiquinol (200 or 100 mg/day) or a placebo. The primary objective was to determine the effect of the ubiquinol supplementation on FMD by the end of the study period. The 8-week randomized, placebo control study determined that, “ubiquinol significantly ameliorated (reduced) dyslipidemia-related endothelial dysfunction. This effect was strongly related to increased nitric oxide bioavailability and was partly mediated by enhanced LDL antioxidant protection.” Of note, “the endothelium modulates the vascular tone mainly through nitric oxide synthesis.” Before you decide to supplement on your own, you should always fist check with your primary care physician for appropriate guidance.