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Nutrition Topics Nutrition ProductsRecipesVitamins & MineralsWeight Management Latest in Nutrition WEB SERIES Maximum Wellness Workout Wednesday LATEST IN WEB SERIES Shop SHOP Brain & Heart Health Bundle & Save CBD Diet & Energy Essential Oils Fitness Accessories Immunity Joints Support & Omegas Lab Tests Men's Health Mocktails Performance Pre-Workout Probiotics & Digestion Protein Targeted Health Vitamins & Minerals Women's Health LATEST PRODUCTS Fitness Fitness Topics Performance Recovery Fitness Essential Amino Acids Support Muscle Protein Synthesis Fitness Maximizing Recovery After Training & Competition Fitness The Keto Diet Plan May Benefit Body Builders Fitness High Intensity Interval Exercise VS Moderate Intensity, Continuous Training Health & Wellness Top Five Tips to Avoid Training too Much Fitness Vitamins and Minerals to Improve Adolescent Fitness Latest in Fitness Health & Wellness Health & Wellness Topics Health & Wellness Products Immunity Men's Health Women's Health Health & Wellness Nutritional Factors May Modify Risk to Covid-19 Health & Wellness COVID-19: Vitamin D May Modulate Risk & Severity Health & Wellness Fish Oil Lowers Cardiovascular Disease Risk Health & Wellness Teenagers Top Five Foods for Success Health & Wellness Research Confirms Optimum Vitamin D Blood Values Vitamins & Minerals Are Multivitamins Right for You? Latest in Health & Wellness Nutrition Nutrition Topics Nutrition Products Recipes Vitamins & Minerals Weight Management Nutrition Top Five Foods to Fight Inflammation Recipes High Protein Blue Berry Pancakes Nutrition The Top Five Healthy Foods for Women High Protein Recipes Egg & Turkey Stuffed Peppers Low Carb Recipes Hearty Breakfast Sausage Nutrition Are Cleansing Supplements Right for You? Latest in Nutrition WEB SERIES WEB SERIESpodcastsMaximum Wellness podcastsRecipes podcastsWorkout Wednesday LATEST IN WEB SERIES Maximum Wellness Maximum Wellness, Episode 120: The Omega-3 Index Is a Diagnostic Tool to Assess Omega-3 Status Date June 1, 2022 Cardiovascular disease (CVD) is still the leading cause of death worldwide. The good news is that modifying CVD risk factors, such as an unhealthy diet, physical inactivity, not smoking, and limiting alcohol intake, can reduce the risk to complications, an early demise, or unnecessary risk to Covid-19 and its pervasive variants. A recent study – Using an Erythrocyte Fatty Acid Fingerprint to Predict Risk of All-Cause Mortality: The Framingham Offspring Cohort – appearing in the June 2021 online issue of the American Journal of Clinical Nutrition (AJCN), sought to compare a combination of RBC (red blood count) FA (fatty acid) levels in predicting all-cause mortality. Those biomarkers included the FA’s measured in blood plasma and RBC membranes, specifically looking at the omega-3’s EPA, and DHA – which are most notably associated with reduced risk to CVD. Those referenced FA’s are found in fish oil and walnuts, among other dietary sources. The study also references a 2018 report, which included 2500 participants in the Framingham Offspring Cohort, who were followed for a median of 7.3 years (i.e., between ages ∼66 and 73 y) – with a baseline RBC EPA + DHA content [the omega-3 index]. A higher omega-3 index was significantly and inversely associated with risk for death from all causes. Those, “individuals in the highest quintile were 33% less likely to succumb during the follow-up years compared with those in the lowest quintile,” comments the AJCN. There have been similar associations seen in the Women’s Health Initiative Memory Study, the Heart and Soul Study, and the Ludwigshafen Risk and Cardiovascular Health Study. However, these prior investigations evaluated only one FA metric, as an exposure variable. The Framingham Offspring Cohort participants (2240 eligible), who had RBC fatty acid measurements and relevant baseline clinical covariates, were without prevalent cardiovascular disease. The participants were evaluated during eleven years of follow-up looking specifically at the association with eight standard risk factors (age, sex, total cholesterol, HDL cholesterol, hypertension treatment, systolic blood pressure, smoking status, and prevalent diabetes) and 28 FA metrics with all-cause mortality. The bottom line is that a physician can now assess the patient’s FA levels – along with their medical history and other appropriate lab values – to prescribe or recommend the appropriate intake level of supplementary omega-3’s – prescription or over the counter preparations.